Tuesday, March 8, 2011

Visual proteomics

Cryo-electron tomography (cryo-ET) gives scientists the power to achieve nanometer scale, 3D imaging of unperturbed cellular environments. Cryo-ET has been successfully used to resolve previously hidden structural details of multi protein complexes and their distribution within cells. Further optimization and combination of cryo-ET with other analytical techniques promises unprecedented insight into the sophisticated protein interactions that drive cellular activity.

Recent advances in sample preparation and analysis have transformed electron microscopy (EM) into a powerful tool for characterizing the molecular organization inside cells. Pairing the novel method of cryo-electron tomography (cryo-ET) with other existing techniques for biological imaging and biochemical analysis could revolutionize the way scientists understand the complex workings of the proteome1,2.

Source and/or read more: http://goo.gl/dHwRq

Publisher and/or Author and/or Editor:__Andres Agostini ─ @Futuretronium at Twitter! Futuretronium Book at http://3.ly/rECc