Ageing and ageing-related disease
Ageing is a complex process of accumulation of damage, and is the major risk factor for the predominant killer diseases in developed countries. A recent breakthrough is the discovery that mutations in single genes can produce a broad-spectrum improvement in healthy ageing in animals models. These findings could lead to development of a new, broad-spectrum, preventative medicine for the diseases of ageing.
Ageing is a natural process whereby the molecules, cells and tissues in a body accumulate damage, leading to loss of function and increased risk of death. Ageing occurs at many levels of organization, including modifications and damage to macromolecules, changes in gene expression, alterations in cellular biochemistry and the metabolome, damage to tissues and the systemic environment, and alterations to the behaviour of the whole system. In developed countries today, ageing is the major risk factor for predominant killer diseases such as cancer, and neurodegenerative and cardiovascular disorders. By understanding the mechanisms of ageing it should be possible to help relieve this disease burden, and to work towards developing interventions to prevent the complications of ageing and ageing-related disease.
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Publisher and/or Author and/or Editor:__Andres Agostini ─ @Futuretronium at Twitter! Futuretronium Book at http://3.ly/rECc